After a neighbor is stabbed, Dr. Choi enlists the help of April to figure out who is the real cause of the incident. Dr. Bekker and Dr. Rhodes expertise is put to the test when Noah misdiagnoses a patient. Dr. Charles is put in an uncomfortable position when Dr. Reese’s estranged father comes to him as a patient without her knowledge. Meanwhile, Dr. Manning rushes to save a baby with whooping cough.
After witnessing a drive-by shooting and hitting her head, Dr. Manning struggles with the aftermath of a head injury. Complicating matters, she and Dr. Halstead deal with a teenage patient and her overbearing older husband, who might not be looking out for his young wife’s best interests. Dr. Rhodes finds himself in a unique situation when he learns alarming information about the woman he went on a date with. Maggie is surprised to discover some unexpected things about the man she has been seeing. Dr. Charles is frustrated when Dr. Reese disobeys his orders and puts herself at risk.
After discovering that a patient’s family might have been abusive, Dr. Choi and April contemplate calling child services. Dr. Manning and Dr. Halstead struggle to see eye to eye in guiding a family who is dealing with their premature baby. Dr. Rhodes is persuaded into performing a risky surgery on Dr. Bekker’s mentor and world renowned surgeon, Dr. Marvin Jaffrey. Meanwhile, Dr. Reese joins Dr. Charles on a visit to the Cook County jail.
Dr. Choi struggles to help a woman cope with anorexia. After a two-week suspension, Dr. Reese is immediately put to the test upon her return by Dr. Charles. Dr. Rhodes takes a stand when one of his patients is forcibly transferred. Meanwhile, Dr. Halstead is on a mission to get Dr. Manning’s son to like him.